发明名称 |
Provision of an insulin growth factor binding protein (IGFBP) and vitronectin-containing complex for modulating cell proliferation |
摘要 |
An isolated protein complex is provided which includes a growth factor, growth factor binding protein and vitronectin. Preferably, the isolated protein complex includes an insulin-like growth factor-I, insulin-like growth factor binding protein-3 or insulin-like growth factor binding protein-5 and vitronectin. Also provided is the use of the protein complex in the manufacture of a medicament for modulating cell proliferation and/or migration for purposes of wound healing, skin repair and tissue replacement therapy. Conversely, by using agents that disrupt growth factor protein complexes formed in vivo, growth factor-driven cell proliferation and/or migration may be suppressed such as for the purposes of treating cancers, psoriasis, atherosclerosis and wounds prone to hypertrophic scarring. |
申请公布号 |
NZ525302(A) |
申请公布日期 |
2005.02.25 |
申请号 |
NZ20010525302 |
申请日期 |
2001.09.24 |
申请人 |
QUEENSLAND UNIVERSITY OF TECHNOLOGY |
发明人 |
UPTON, ZEE;KRICKER, JENNIFER ANN |
分类号 |
C12N15/09;A61K38/00;A61K38/30;A61L27/00;A61P1/00;A61P1/04;A61P5/00;A61P9/10;A61P17/02;A61P17/06;A61P19/00;A61P19/04;A61P19/10;A61P25/00;A61P35/00;A61P37/00;A61P43/00;C07K14/47;C07K14/475;C07K14/485;C07K14/50;C07K14/51;C07K14/71;C07K14/75;C07K14/78;C07K14/79;C07K19/00;C12N5/10;(IPC1-7):A61K38/30 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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