Modulation of smooth muscle cell proliferation

摘要

A nucleic acid molecule encoding a CUB domain polypeptide comprising an amino acid sequence consisting of the amino acid position 40 to 150 of Figure 1A, a vector comprising the nucleic acid molecule and a polypeptide comprising an amino acid sequence consisting of the amino acid position 40 to 150 of Figure 1A can be used in the manufacture of a medicament for stimulating smooth muscle cell proliferation in non-human tissues and organs. An antibody capable of binding to a CUB domain polypeptide comprising an amino acid sequence consisting of the amino acid position 40 to 150 of Figure 1A can be used in the manufacture of a medicament for treating or preventing any of atherosclerosis, neointimal hyperplasia caused by artery anastomosis or balloon catheter, postangioplasty restenosis caused by arterial stenting after percutaneous transluminal coronary angioplasty. With the proviso that the polypeptide does not comprise the entire amino acid sequence listed in Figure 1A. Also described are nucleic acid molecules encoding a VEGF-X polypeptide comprising an amino acid sequence according to Figure 1A or encoding a CUB domain polypeptide comprising an amino acid sequence consisting of the amino acid position 40 to 150 of Figure 1A, vectors comprising the nucleic acid molecules and the polypeptides can be used in the manufacture of a medicament for treating or preventing urethral dysfunction, bladder dysfunction, sphincter dysfunction or for pelvic floor reconstruction.