| 摘要 |
<p>3-Aminopyrazinamides (I), their salts & pharm. compns. contg. them. X = H,Cl,Br,I,CF3, alkyl, cycloalkyl, Ph, Cl/Br-phenyl, phenalkyl, alkyl-S/SO2, phenalkyl-S/SO2/amino, alkoxy, mono/dialkyl-amino, piperidino, pyrrolidino Y = H, OH, SH, alkoxy, alkyl-S, alkyl, CF3, cycloalkyl, Ph, pyrrolidinyl, hexahydro-1-azepinyl, 4-alkyl-1-piperazinyl, NR5R6 R6 = H, alkyl R5 = H, NH2, alkoxy, Ph, halophenyl, alkyl, unsatd. alkyl, cycloalkyl, cycloalkyl-alkyl, hydroxy/haloalkyl, dialkylamino, phenalkyl, halo/alkylphenalkyl, furylalkyl R = amino/alkylamino/dialkylamino/morpholino/pyrrolidinyl/piperidino/- hexahydro-1-azepinyl/octahydro-1-azocinyl-ethyl,4-alkyl-1-piperaz- inyl-propyl, pyridylmethyl,l-alkyl-2-pyrrolidinylmethyl,1-alkyl-3-pyrrolidinyl R1 = H,alkyl R2 = H, alkyl, alkoxy/dialkylamino/furyl-alkyl, phenalkyl, halo/alkyl/alkoxy-phenalkyl, alkanoyl, phenalkanoyl; when R1,2 = alkyl, they may be joined to form a 6-membered ring with the N (all 'alkyls' are 'lower alkyls') As diuretic &/or saluretic agents; doses: 5-750 mg./day.</p> |
