发明名称 |
COMBINATION OF HISTONE DEACETYLASE INHIBITORS WITH CHEMOTHERAPEUTIC AGENTS |
摘要 |
The invention relates to a combination which comprises (a) one or more chemotherapeutic agents and (b) a histone deacetylase inhibitor ("HDAI") for simultaneous, concurrent, separate or sequential use, especially for use in the treatment of proliferative diseases including pre-malignant lesions (e.g. colon polyps) and malignancies, both solid and undifferentiated or other proliferative diseases in a mammal, particularly a human. The invention also relates to pharmaceutical compositions comprising such a combination and to a method of preventing or treating proliferative diseases including pre-malignant lesions (e.g. colon polyps) and malignancies, both solid and undifferentiated or other proliferative diseases, in a mammal, particularly a human, with such a combination. The present invention further also relates to a commercial package or product comprising such a combination. |
申请公布号 |
WO2004103358(A3) |
申请公布日期 |
2005.02.17 |
申请号 |
WO2004EP05433 |
申请日期 |
2004.05.19 |
申请人 |
NOVARTIS AG;NOVARTIS PHARMA GMBH;ATADJA, PETER, WISDOM;REMISZEWSKI, STACY, WILLIAM;TROGANI, NANCY |
发明人 |
ATADJA, PETER, WISDOM;REMISZEWSKI, STACY, WILLIAM;TROGANI, NANCY |
分类号 |
A61K31/16;A61K31/4045;A61K31/4745;A61K31/513;A61K31/704;A61K31/7068;A61K45/06;A61P35/00;A61P35/04 |
主分类号 |
A61K31/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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