| 摘要 |
A method for synthesising a given peptide or its derivative which contains a proline residue or a proline derivative, at proximity to, or at, the C- terminal end of said peptide is provided. The method comprises a) synthesisi ng on a first resin a C~terminal portion of said peptide, o r its derivative, comprising at least three successive amino acid residues or their derivative s, by successive coupling of selected amino acids, small peptides or their derivatives, b) cleaving the C-terminal portion from said first resin; c) reattaching said C-terminal portion to a second resin which is generally suitable for the synthesis of peptides but is unsuitable for the formation o f peptides having a proline residue positioned atthe C-terminal end of said peptide; and d)coupling selected amino acids, small peptides or derivatives to the C-terminal portion.
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