THERAPEUTIC USES OF HMGN1 AND HMGN2

摘要

This application discloses methods of modulating integumentary prolifération or development, such as prolifération of the dermis, epidermis, sweat glands, and sebaceous glands, by modulating the level of HMGN1 or HMGN2 activity. For example, integumentary prolifération or development increases in the absence of HMGN1 or HMGN2 activity, while integumentary prolifération or development decreases in the presence of HMGN1 or HMGN2 activity. Methods are also provided for modulating the rate of hair growth cycling. Methods are also provided for increasing repair of DNA-damage, for example regulating sensitivity to UV-induced DNA damage by modulating the level of HMGN1 or HMGN2 activity. For example, increasing HMGN1 activity decreases sensitivity to UV, and thus increases the rate of repair of UV-damaged DNA.