发明名称 |
SYNTHESE EINES NEUARTIGEN PARAMAGNETISCHEN AMINO-SÄURE-DERIVATES ZUR KENNZEICHNUNG CHEMISCHER UND BIOLOGISCHER MAKROMOLEKÜLE |
摘要 |
<p>The present invention refers to the synthesis and application of 2,2,5,5-tetramethylpyrrolidine-N-oxyl-(9-fluorenylmethyloxycarbonyl)-3-amine-4-carboxylic acid, a novel paramagnetic amino acid derivative (spin label), denominated Fmoc-Poac. Fmoc-Poac can be coupled to peptide sequences and other molecules or systems. It can be inserted anywhere in a peptide segment, even at an internal position if necessary, after removal of its temporary amine protecting group, Fmoc. Owing to its pyrrolidine structure, this molecule may induce differentiated conformations as compared with normal alpha-amino acids, thus being a valuable probe for structural-biological activity of several relevant peptides. The Poac-angiotensin II analogue was synthesized as a model according to its use as a chemical derivative.</p> |
申请公布号 |
DE60017413(D1) |
申请公布日期 |
2005.02.17 |
申请号 |
DE2000617413 |
申请日期 |
2000.06.21 |
申请人 |
CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTIFICO E TECNOLOGICO - CNPQ, BRASILIA |
发明人 |
NAKAIE, RYUICHI;TOMINAGA, MINEKO;DE MATTOS PAIVA, CECHELLI;DOS REIS BARBOSA, SIMONE;MARCHETTO, REINALDO;SCHREIER, SHIRLEY |
分类号 |
C07D207/46;(IPC1-7):G01N33/58;C07K7/14 |
主分类号 |
C07D207/46 |
代理机构 |
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