TREFOIL FACTOR 3 (TFF3) AS A TARGET FOR ANTI-CANCER THERAPY

摘要

The present invention is directed to methds of treating and preventing cance r, such as cancer characterized by differential expression of trefoil factor 3 (TFF3). The methods include administering to a patient an agent that modulat es TFF3 activity or expression. The present invention is further directed to reducing the physiological effects of TFF3 expression in cells, including inhibiting cell motility and resistance to apoptosis. Oligonucleotides and antibodies that can modulate expression or activity of TFF3 are also provide d.