TRUNCATED FRAGMENTS OF ALPHA-SYNUCLEIN IN LEWY BODY DISEASE
摘要
The application identifies novel fragments of alpha-synuclein in patients with Lewy Body Disease (LBD) and transgenic animal models thereof. These diseases are characterized by aggregations of alpha-synuclein. The fragments have a truncated C-terminus relative to full-length alpha-synuclein. Some fragments are characterized by a molecular weight of about 12 kDa as determined by SDS gel electrophoresis in trycine buffer and a truncation of at least ten contiguous amino acids from the C-terminus of natural alpha-synuclein. The site of cleavage preferably occurs after residue (117) and before residue (126) of natural alpha-synuclein. The identification of these novel fragments of alpha-synuclein has a number of application in for example, drug discovery, diagnostics, therapeutics, and transgenic animals.
申请公布号
WO2005013889(A2)
申请公布日期
2005.02.17
申请号
WO2004US15836
申请日期
2004.05.19
申请人
ELAN PHARMACEUTICALS, INC.;CHILCOTE, TAMIE, J.;GOLDSTEIN, JASON;ANDERSON, JOHN, P.
发明人
CHILCOTE, TAMIE, J.;GOLDSTEIN, JASON;ANDERSON, JOHN, P.