| 摘要 |
1,208,848. Antibiotic 17,967 R.P. RHONEPOULENC S.A. 12 May, 1969 [13 May, 1968], No. 24182/69. Heading C2A. The novel antibiotic 17,967 R.P. is a yellow microcrystalline powder, m.p. 290-300‹ C. (decomp.), which is soluble in D.M.F., relatively soluble in pyridine, very slightly soluble in water, acetone and methanol, and insoluble in diethyl ether, hexane and cyclohexane, it has the composition C = 61À5%, H = 5À25%, O = 20À0%, N = 12À5%, its U.V. spectrum (10À5 mg/l. in D.M.F.) shows absorption maxima at 268 n.m. (E<SP>1%</SP> 1cm. = 377) and 368 n.m. (E<SP>1%</SP> 1cm. = 707) and an absorption minimum at 285 n.m. (E<SP>1%</SP> 1cm. = 281), its I.R. spectrum is as in Fig. 2, and its optical rotation is [α]<SP>20</SP> D = + 103 degrees Œ 2 degrees (C = 0À5 D.M.F.); and is prepared by aerobically cultivating Streptomyces roseopullatus DS 20,073 (NRRL 3430) or a 17,967 R.P.-producing mutant thereof. Pharmaceutical compositions comprise 17,967 R.P. and a pharmaceutically-acceptable carrier.
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