METHODS AND SYSTEMS FOR THE ANNOTATION OF BIOMOLECULE PATTERNS IN CHROMATOGRAPHY/MASS-SPECTROMETRY ANALYSIS

摘要

The method and measurement system according to the invention performs combin ed Chromatography and Mass Spectrometry analysis and comprises the steps of: performing an C/MS analysis (300); generating at least one first elution profile (305), wherein one dimension is an elution time of the chromatograph y, and one dimension is mass to charge ratio (m/z), and at least one dimension a signal intensity, and the signal from each biomolecule species is dispersed forming a plurality of signal peaks associated with each biomolecule species in the elution profile; and reassembling (310) the dispersed signal originating from one biomolecule species in the elution profile. The reassembling comprises an automated annotation adapted to reassemble signal variations in the elution profile that originate from the same biomolecule species and generating a biomolecule map. The automated annotating is simultaneously based on both the elution time-dimension and the m/z-dimensio n.