发明名称 METHOD OF RESOLVING AMLODIPINE RACEMATE.
摘要 <p>The invention relates to methods of resolving racemic amlodipine into enantiomerically enriched compositions by precipation with tartaric acid in the presence of a non-aqueous solvent, such as N,N'-dimethylacetamide. The molar ratio of tartaric acid:amlodipine is preferably less than 0.25:1.0 greater than 0.75:1.0.</p>
申请公布号 MXPA04003877(A) 申请公布日期 2005.02.17
申请号 MX2004PA03877 申请日期 2002.10.23
申请人 SEPRACOR, INC. 发明人 ANDREI A. ZLOTA
分类号 A61K31/4422;A61P9/10;A61P9/12;C07D211/90;(IPC1-7):C07D211/90 主分类号 A61K31/4422
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