| 摘要 |
An apparatus for refolding proteins and a method of using an apparatus for refolding proteins is provided in which a refolding process for proteins can be carried out for various proteins, efficiently and accurately, and without manual intervention. The construction comprises: a transport section on which either one or two or more vessels capable of holding a protein solution containing a protein to be refolded are placed, which transports the vessels along a predetermined closed transport path; an optical measurement section provided on the transport path, which measures the optical properties of the protein solution within the vessel; a pH measuring section provided on the transport path, which measures the pH of the protein solution within the vessel; and a reagent supply section provided on the transport path, capable of supplying each of a plurality of types of reagent including reagents for adjusting the pH of the protein solution within the vessel, wherein the reagent supply section performs protein refolding by adjusting the pH of the protein solution based on the measurement results of the optical measurement section, the measurement results of the pH measuring section, and a predetermined pH pattern.
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