COMPOUND LIBRARIES OF SPIRO-BENZODIOXINE-PIPERIDINES

摘要

The present invention provides a compound library designed to target a large group of receptors that recognise electron rich aromatic ring systems. These receptors fall into two main groups, those that also require a positively charged amine in the ligand (for example the adrenoceptors or the serotonin receptors) and those that do not (for example the melanocortin, vasopressin, and melatonin receptors). A combination of specific motifs R1 and R2 are appeneded form the central scaffold and are designed to pick up different interactions at the receptor site. The library comprises or consists of a set of structurally related compounds of general formula (I).