BISPECIFIC ANTIBODIES FOR INDUCING APOPTOSIS OF TUMOR AND DISEASED CELLS
摘要
The bispecific antibodies of the present invention are in the form of a heteroconjugate that inhibits growth and induces apoptosis of a diseased cell and that does not require the recruitment of effector cells. The heteroconjugate has at least two binding arms wherein each of the binding arms possesses a different specificity and need not have apoptotic activity when not conjugated to each other. Also provided are methods of treating and diagnosing a diseased cell using the bispecfic antibodies of the present invention.
申请公布号
WO2005014618(A2)
申请公布日期
2005.02.17
申请号
WO2004US25840
申请日期
2004.08.09
申请人
IMMUNOMEDICS, INC.;CHANG, CHIEN-HSING;GOLDENBERG, DAVID, M.;HANSEN, HANS, J.;HORAK, EVA;HORAK, IVAN
发明人
CHANG, CHIEN-HSING;GOLDENBERG, DAVID, M.;HANSEN, HANS, J.;HORAK, EVA;HORAK, IVAN