NUCLEOSIDE CAPABLE OF RELEASING FUNCTIONAL UNIT THROUGH OXIDATION AND PROCESS FOR PRODUCING OLIGONUCLEOTIDE CONTAINING THE SAME

摘要

A method of easily releasing a useful substance bonded to oligonucleotide without impairing a target nucleic acid; and a novel base therefor. A nucleoside or nucleotide (oligonucleotide containing the same) represented by the formula: (I) (wherein each of X and Y independently represents -O-, -NH-, -N(alkyl)- or -S-; R represents a functional unit, a reporter unit or a biofunctional molecule; each of R<1> and R<2> independently represents a hydrogen atom, a phosphate bond group, a phosphoramidite group or a nucleotide; and n is a numeral of 1 to 10). There is further provided a method of releasing the R group moiety at base portion by the use of the oligonucleotide comprising the nucleotide.