发明名称 |
5c8 Antigen |
摘要 |
This invention provides a monoclonal antibody which specifically recognizes and forms a complex with a protein located on the surface of activated T cells and thereby inhibits T cell activation of B cells. This invention also provides the monoclonal antibody 5c8 (ATCC Accession No. ______). This invention provides a human CD4<-> T cell leukemia cell line designated D1.1 (ATCC Accession No. ______) capable of constitutively providing contact-dependent helper function to B cells. This invention also provides an isolated protein from the surface of activated T cells, wherein the protein is necessary for T cell activation of B cells. This invention further provides an isolated, soluble protein from the surface of activated T cells, wherein the protein is necessary for T cell activation of B cells.
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申请公布号 |
US2005037005(A1) |
申请公布日期 |
2005.02.17 |
申请号 |
US20040943442 |
申请日期 |
2004.09.17 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY |
发明人 |
LEDERMAN SETH;CHESS LEONARD;YELLIN MICHAEL J. |
分类号 |
G01N33/50;A61K35/76;A61K38/00;A61K38/17;A61K39/00;A61K39/395;A61K47/48;A61K48/00;A61K49/00;A61K51/10;A61P3/10;A61P5/14;A61P7/04;A61P7/06;A61P17/06;A61P19/02;A61P21/04;A61P29/00;A61P31/14;A61P35/00;A61P35/02;A61P37/00;A61P37/02;A61P37/06;A61P37/08;A61P43/00;C07K14/47;C07K14/705;C07K14/725;C07K16/28;C12N1/15;C12N1/19;C12N1/21;C12N5/08;C12N5/09;C12N5/10;C12N15/02;C12N15/09;C12N15/12;C12N15/13;C12P21/02;C12P21/08;C12Q1/02;C12R1/91;G01N33/15;G01N33/53;G01N33/566;G01N33/574;G01N33/577;(IPC1-7):A61K39/395 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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