发明名称 |
Use of telmisartan and simvastatin for treatment or prophylaxis of cardiovascular, cardiopulmonary and renal diseases e.g. hypertension combined with hyperlipidemia or atherosclerosis |
摘要 |
<p>The use of the angiotensin II receptor antagonist telmisartan (I) (or its salt) and the 3-hydroxy-2-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor simvastatin (II) is claimed in the production of medicaments (A) for the treatment or prophylaxis of cardiovascular, cardiopulmonary or renal diseases. Independent claims are included for corresponding treatment methods and pharmaceutical compositions. ACTIVITY : Cardiant; Vasotropic; Hepatotropic; Hypotensive; Antilipemic; Antiarteriosclerotic; Antiasthmatic; Antiinflammatory; Antidiabetic; Cerebroprotective; Antianginal; Cytostatic; Antibacterial; Immunosuppressive; Vulnerary; Osteopathic; Neuroprotective; Nootropic. MECHANISM OF ACTION : Angiotensin II receptor antagonist; HMG-CoA reductase inhibitor; Peroxisome proliferator activated receptor-gamma (PPAR-gamma ) regulating gene expression inducer; Matrix metalloproteinase MMP-9 expression controller; Cytokine CD40L antagonist.</p> |
申请公布号 |
DE10335027(A1) |
申请公布日期 |
2005.02.17 |
申请号 |
DE2003135027 |
申请日期 |
2003.07.31 |
申请人 |
BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG |
发明人 |
KAUSCHKE, STEFAN;MARK, MICHAEL |
分类号 |
A61K31/401;A61K31/416;A61K31/4184;A61K45/00;A61K45/06;A61P3/10;A61P5/50;A61P9/12;(IPC1-7):A61K45/00 |
主分类号 |
A61K31/401 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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