Methods and compositions for treating and preventing autoimmune disorders

摘要

The invention features methods for reducing, treating, or preventing autoimmune disorders by administering NTDPases, or alternatively, P2 receptor inhibitors to a mammal in need thereof. The invention also features methods for diagnosing a mammal as having or at risk of having an autoimmune disorder by detecting the biological activity of NTPDases or P2 receptors. Also disclosed are screening methods that make use of NTPDases and P2 receptors for the identification of novel therapeutics for autoimmune disorders.