发明名称 |
Immune activation by double-stranded polynucleotides |
摘要 |
Double-stranded polynucleotide activates the expression of immune recognition molecules. The polynucleotide can have a minimal length and activates the expression of molecules not encoded by a nucleotide sequence that is not necessarily related to the polynucleotide. The present invention provides for a simple and specific system to activate expression of Class I and/or Class II molecules of the major histocompatibility complex (MHC), and allows regulation of expression of MHC molecules on the cell-surface of antigen presenting cells and other immune cells. Also provided are systems for the screening, identification, and isolation of compounds that increase or decrease this activation.
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申请公布号 |
US2005036993(A1) |
申请公布日期 |
2005.02.17 |
申请号 |
US20040830898 |
申请日期 |
2004.04.22 |
申请人 |
KOHN LEONARD D.;SUZUKI KOICHI;MORI ATSUMI;IISHI KEN;KLINMAN DENNIS M.;RICE JOHN M. |
发明人 |
KOHN LEONARD D.;SUZUKI KOICHI;MORI ATSUMI;IISHI KEN;KLINMAN DENNIS M.;RICE JOHN M. |
分类号 |
A61K31/4164;C12N5/071;C12N5/077;(IPC1-7):G01N33/53;A61K48/00;C12N15/85 |
主分类号 |
A61K31/4164 |
代理机构 |
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地址 |
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