The present invention provides a method for identifying a drug-like compound, or lead compound for the development of a drug-like compound, which is capable of modulating cellular adhesion and/or cell survival comprising the step of testing said compound for an ability to modulate the binding of a complex of tissue transglutaminase and fibronectin to a heparan sulfate containing receptor. In particular, there is provided a method for identifying a compound for use in the curative and/or prophylactic treatment of a proliferative disorder or with efficacy in promoting wound healing and /or cell survival, and compounds identified by such methods.
申请公布号
WO2004070386(A3)
申请公布日期
2005.02.17
申请号
WO2004GB00439
申请日期
2004.02.05
申请人
THE NOTTINGHAM TRENT UNIVERSITY;TELCI, DILEK;VERDERIO-EDWARDS, ELISABETTA;GRIFFIN, MARTIN
发明人
TELCI, DILEK;VERDERIO-EDWARDS, ELISABETTA;GRIFFIN, MARTIN