| 摘要 |
<p>Provided are fluorescent substrates for beta-lactamases having the general formula I: in which R is a benzyl, 2-thienylmethyl, or cyanomethyl group; R' is selected from the group consisting of H, physiologically acceptable salts or metal, ester groups, ammonium cations, -CHR<SUB>2</SUB>OCO(CH<SUB>2</SUB>)<SUB>n</SUB>CH<SUB>3</SUB>, -CHR<SUB>2</SUB>OCOC(CH<SUB>3</SUB>)<SUB>3</SUB>, acylthiomethyl, acyloxy-alpha-benzyl, deltabutyrolactonyl, methoxycarbonyloxymethyl, phenyl, methylsulphinylmethyl, beta-morpholinoethyl, dialkylaminoethyl, and dialkylaminocarbonyloxymethyl, in which R<SUB>2 </SUB>is selected from the group consisting of H and lower alkyl; A is selected from the group consisting of S, O, SO, SO<SUB>2 </SUB>and CH<SUB>2</SUB>; and Z is a donor fluorescent moiety. Also provided are methods of use of the compound of general formula I.</p> |
