发明名称 |
Antisense modulation of BCL-X expression |
摘要 |
<p>Compositions and methods are provided for modulating the expression of bcl-x. Antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding bcl-x are preferred. Methods of using these compounds for modulation of bcl-x expression and for treatment of diseases associated with expression of bcl-x are also provided. Methods of sensitizing cells to apoptotic stimuli are also provided.</p> |
申请公布号 |
EP1507005(A2) |
申请公布日期 |
2005.02.16 |
申请号 |
EP20040077688 |
申请日期 |
1999.09.28 |
申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
NICKOLOFF, BRIAN J.;MONIA, BRETT P.;DEAN, NICHOLAS M.;BENNETT, C. FRANK;ZHANG, QINGQING |
分类号 |
C12N15/09;A61K9/10;A61K31/337;A61K31/711;A61K31/7115;A61K31/712;A61K31/7125;A61K33/24;A61K38/00;A61K48/00;A61P35/00;A61P43/00;C07H21/04;C12N5/10;C12N15/113;C12R1/91;(IPC1-7):C12N15/11;C07H21/02;C12N15/85;C12N15/86 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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