发明名称 |
Method to prepare conjugates of factor VIII and a biocompatible polymer |
摘要 |
<p>The invention relates to a conjugate of factor VIII and a biocompatible polymer, said conjugate obtainable by a process comprising: (a) immobilizing factor VIII by interaction with a group-specific adsorbent carrying anionic-exchange ligands; (b) activating a biocompatible polymer; (c) conjugating the activated biocompatible polymer to external sites of the immobilized factor VIII; and (d) eluting the conjugate from the adsorbent. <IMAGE></p> |
申请公布号 |
EP1258497(B1) |
申请公布日期 |
2005.02.16 |
申请号 |
EP20020013613 |
申请日期 |
1996.09.27 |
申请人 |
BIOVITRUM AB |
发明人 |
ROESTIN, JOHANNA;SANDBERG, HELENA;SMEDS, ANNA-LISA;AKERBLOM, EVA |
分类号 |
C07K1/06;A61K38/00;A61K47/48;C07K1/107;C07K14/745;C07K14/755;C07K17/00;C12N9/64;C12N9/96;(IPC1-7):C07K14/755 |
主分类号 |
C07K1/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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