Processes for resolving piperidyl acetamide stereoisomers

摘要

The present invention provides a synthetic process comprising the steps of:
providing d,l-threo piperidyl acetamide stereoisomers having formulas:
wherein R 1 is aryl having about 6 to about 28 carbon atoms; and
reacting said stereoisomers with dibenzoyl-D-tartaric acid in an organic solvent, thereby forming acid salts of said d-threo stereoisomers preferentially with respect to said I-threo stereoisomers.