发明名称 |
Substituted indolines with an inhibitory effect on various kinases and complexes of CDKs |
摘要 |
The present invention relates to new substituted indolinones of general formulawhereinX and R1 to R5 are defined as in claim 1, the isomers and the salts thereof which have valuable properties.The above compounds of general formula I wherein R1 denotes a hydrogen atom, a C1-3-alkyl group or a prodrug group have valuable pharmacological properties, particularly an inhibiting effect on various kinases, on viral cyclin and on receptor tyrosine kinases, and the other compounds of the above general formula I wherein R1 does not represent a hydrogen atom, a C1-3-alkyl group or a prodrug group are valuable intermediate products for the preparation of the abovementioned compounds.
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申请公布号 |
US6855710(B2) |
申请公布日期 |
2005.02.15 |
申请号 |
US20030666643 |
申请日期 |
2003.09.19 |
申请人 |
BOEHRINGER INGELHEIM PHARMA KG |
发明人 |
WALTER RAINER;GRELL WOLFGANG;HECKEL ARMIN;HIMMELSBACH FRANK;EBERLEIN WOLFGANG;ROTH GERALD;VAN MEEL JACOBUS C.A.;REDEMANN NORBERT;SPEVAK WALTER;TONTSCH-GRUNT ULRIKE;VON RUEDEN THOMAS |
分类号 |
C07D401/12;A61K31/40;A61K31/403;A61K31/4035;A61K31/404;A61K31/4427;A61K31/4439;A61K31/454;A61K31/496;A61K31/506;A61K31/5377;A61K31/541;A61P35/00;A61P43/00;C07D;C07D209/34;C07D209/36;C07D209/48;C07D401/14;C07D403/12;(IPC1-7):C07D401/12 |
主分类号 |
C07D401/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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