| 摘要 |
1,250,981. Benzothiadiazole derivatives. CHARLES E. FROSST & CO. 19 May, 1969 [22 May, 1968], No. 25335/69. Heading C2C. Compounds of the general formula (R<SP>1,2,4</SP> = H, C 1-3 alkyl; R<SP>3</SP>=H, PhCO, C 2-4 alkanoyl; R5=H, C 1-5 alkyl, Ph-(C 1-3 alkyl), C 2-5 alkanoyl; R<SP>6</SP> = C 1-20 alkyl, C 2-6 alkenyl or alkynyl, Ph, C 3-6 cycloalkyl, 5-6 membered heterocyolic group, each optionally substituted, or NR<SP>5+6</SP> = 4-7 membered ring which may contain, in addition to but not adjacent to the nitrogen atom, one or two heteroatoms selected from O, S, N and which may be substituted by one or more C 1-3 alkyl groups) and their salts are prepared by standard methods, e.g. from the corresponding epoxide and amine or by reducing a compound containing an amine group precursor, optionally followed by acylation and/or salt formation. The above compounds are #-adrenergic blocking agents, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier. |
