发明名称 |
Aromatiske carboxylsyreestere, fremstillingen deraf og anvendelsen deraf som lægemiddel |
摘要 |
A compound of the formula wherein R1 is hydrogen or C1-6-alkyl; R2 is C1-6-alkyl or adamantyl; R3 is C1-6-alkyl or hydroxy; or R2 and R3 taken together are -(CR6R7)n-; R4 is C2-8-alkyl, C2-8-alkenyl, C2-8-alkynyl, -OCH2R5 or C2-8-alkanoyl; and hydrogen when R3 is hydroxy; R5 is C1-6-alkyl, C2-6-alkenyl or C2-6-alkynyl; R6 and R7 are hydrogen or C1-6-alkyl; Y is oxygen or sulphur; and n is 3, 4 or 5, and pharmaceutically usable salts of carboxylic acids of formula I act as selective ligands of retinoic acid gamma -receptors and are useful for the treatment of epithelial lesions. |
申请公布号 |
DK0862554(T3) |
申请公布日期 |
2005.02.14 |
申请号 |
DK19960934302T |
申请日期 |
1996.11.05 |
申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
KLAUS, MICHAEL;MOHR, PETER |
分类号 |
C07D213/79;A61K31/44;A61K31/455;A61K31/57;A61P17/00;A61P17/02;A61P35/00;A61P43/00;C07D213/80;C07D213/803;C07D215/48;(IPC1-7):C07D213/80 |
主分类号 |
C07D213/79 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|