发明名称 |
METABOLITE OF XANTHINE PHOSPHODIESTERASE 5 INHIBITOR AND DERIVATIVES THEREOF USEFUL FOR TREATMENT OF ERECTILE DYSFUNCTION |
摘要 |
<p>The present invention is directed to a metabolite of a xanthine Phosphodiesterase type 5 inhibitor having the following structure derivatives, and formulations thereof, and processes for preparing the same. Further disclosed are methods of treating a physiological disorder, symptom or disease in a patient, comprising administering to the patient an effective amount of the above compound, wherein the physiological disorder, symptom or disease is a urogenital, cardiovascular, cerebrovascular or peripheral vascular disorder, angina pectoris, hypertension, restenosis post angioplasty, endarterectomy, stent introduction, cerebral stroke, a respiratory tract disorder such as an allergic condition associated with atopy, pulmonary hypertension, an ischemic heart disorder, impaired glucose tolerance, diabetes and its related complication, insulin resistance syndrome, hyperglycemia, polycystic ovarian syndrome, a glomerular disorder, renal insufficiency, nephritis, a tubular interstitial disorder, an autoimmune disorder, glaucoma, intestinal motility, cachexia or cancer.</p> |
申请公布号 |
WO2005012303(A1) |
申请公布日期 |
2005.02.10 |
申请号 |
WO2004US24525 |
申请日期 |
2004.07.29 |
申请人 |
SCHERING CORPORATION;GHOSAL, ANIMA;TONG, WEI;CHOWDHURY, SWAPAN, K.;ZBAIDA, SHMUEL;WIRTH, MARK, A.;ALTON, KEVIN, B.;PATRICK, JAMES, E.;BOYLE, CRAIG, D.;STAMFORD, ANDREW |
发明人 |
GHOSAL, ANIMA;TONG, WEI;CHOWDHURY, SWAPAN, K.;ZBAIDA, SHMUEL;WIRTH, MARK, A.;ALTON, KEVIN, B.;PATRICK, JAMES, E.;BOYLE, CRAIG, D.;STAMFORD, ANDREW |
分类号 |
C07D473/06;(IPC1-7):C07D473/06;A61K31/522 |
主分类号 |
C07D473/06 |
代理机构 |
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