Compounds, compositions and methods are provided for modulating the expression of HIF1a and/or HIF2a. The compositions comprise oligonucleotides, targeted to nucleic acid encoding HIFlalpha and HIF2alpha. Methods of using these compounds for modulation of HIFlalpha and/or HIF2alpha expression and for diagnosis and treatment of disease associated with expression of HIFlalpha and/or HIF2alpha are provided.
