摘要 |
The present invention provides compositions and methods for diagnosing Alzheimer's disease (AD). In particular, the present invention provides monoclonal antibodies that specifically bind to soluble, non-fibrillar oligomeric amyloid beta protein assemblies proteolytically derived from the transmembrane amyloid precursor protein (APP) while not reacting with fibrillar amyloid beta protein assemblies, monoclonal antibodies that specifically bind to fibrillar amyloid beta protein assemblies that do not react with soluble, non-fibrillar oligomeric amyloid beta protein assemblies, and methods of use of these compositions in the diagnosis of Alzheimer's disease, as well as methods to monitor treatment and/or disease progression of AD in patients. |
申请人 |
NORTHWESTERN UNIVERSITY;LADU, MARY, JO;BINDER, LESTER;STINE, BLAINE, I.;MANELLI, ARLENE |
发明人 |
LADU, MARY, JO;BINDER, LESTER;STINE, BLAINE, I.;MANELLI, ARLENE |