PYRIDINYLAMINO-PYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS

摘要

The present invention relates to compounds of formula I, or pharmaceutically acceptable salts thereof, wherein: (A) "a" is a single bond and "b" is a double bond; R<1> and R<2> are each independently as defined below; R<10> is absent; or (B) "a" is a double bond and "b" is a single bond; R<1> is oxygen; R<2> is as defined below; and R<10> is H or alkyl; X is S, O, NH, or NR <7>; Y is N or CR<8>; one of Z<1>, Z<2>, and Z<3> is N or N<+>R<a> and the remainder are each independently CR<7>; R<1>, R<2>, R<5> and R<6> are each independently R<7>; R<3> and R<4> are each independently R<8>; each R<7> is independently H, halogen, NR<b>R<C>, OR<d> or a hydrocarbyl group optionally substituted by one or more R<9> groups; each R<8 >is independently H or (CH2)R<9>, where n is 0 or 1; each R<9> is independently selected from H, halogen, NO2, CN, R<e>, NHCOR<f>, CF3, COR<g>, NR<h>R , CONR<J>R<k>, SO2NR<1>R<m>, SO2R<n>, OR<p>, OCH2CH2OR<q>, morpholine, piperidine and piperazine; and R<a-q >are each independently H or alkyl, wherein said alkyl group is optionally substituted by one or more R<9> groups; where the compound is other than [4-(2,4-dimethyl-thiazol-5-yl)-pyrimidin-2-yl]-pyridin­2-yl-amine and 4-[4-fluorophenyl)-1-(1-methyl-4-piperidinyl)-1H-imidazol-5-yl]-N-4­pyridinyl-2-pyrimidinamine. Further aspects of the invention relate to the use of compounds of formula I in the treatment of proliferative disorders, viral disorders, CNS disorders, strokes, alopecia and/or diabetes.