BENZIMIDAZOLE, BENZTHIAZOLE AND BENZOXAZOLE DERIVATIVES AND THEIR USE AS LTA4H MODULATORS

摘要

Leukotriene A4 hydrolase (LTA4H) inhibitors of Formula (I), compositions containing them, and their use for the inhibition of LTA4H enzyme activity a nd the treatment, prevention or inhibition of inflammation and/or conditions associated with inflammation. Wherein X is selected from the group consistin g of NR5, O, and S, with R5 being on of H and CH3; Y is selected from the grou p consisting; W is selected from the group consisting Of CH2 and CHR1-CH2,with R1 being one H and OH, wherein R1-attached carbon member in said CHR1-CH2 is not directly attached; R4 is selected from the group consisting of H, OCH3, CI, F Br, OH, NH2, CN, CF3 and CH3; R6 is H or F; and R2 and R3 are each independently selected from various groups.