| 摘要 |
Novel block copolymers are described, together with the production therefrom of physiologically soluble polymer therapeutics. The block copolymers have the general formula (I) wherein R is selected from the group consisting of hydrogen, C1-C18 alkyl, C2-C18 alkenyl, C7-C18 aralkyl, C7-C18 alkaryl, C6-C18 aryl, carboxylic acid, C2-C18 alkoxycarbonyl, C<2>-C18 alkaminocarbonyl, or any one of C1-C18 alkyl, C2-C18 alkenyl, C7-C18 aralkyl, C7-C18 alkaryl, C6-C18 aryl, C2-C18 alkoxycarbonyl and C2-C18 alkaminocarbonyl substituted with a heteroatom within, or attached to, the carbon backbone: R<1 >is selected from the group consisting of hydrogen and C1-C6 alkyl groups; R<2 >is a linking group; X is an electron withdrawing group; R<3 >is selected from the group consisting of C1-C15 alkylene, C2-C15 alkenylene, C7-C15 aralkylene, C7-C18 alarylene and C6-C18 arylene; l, is a divalent linker joining the of C1-C18 alkylene, C2-C18 alkylene, C2-C18 aralkylene, C7-C18 alarylene and C6-C18 arylene; l, is a divalent linker joining the blocks; and m and n are each an integer of greater than 1.
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