发明名称 Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives
摘要 The invention relates to novel synthesis methods for the preparation of the intermediates, which are suitable for the preparation of statin derivatives, especially to novel synthesis methods of the intermediate of formula VI wherein Ra and Rc are each independently of the other hydrogen or a hydroxy-protecting group or together are a bridging hydroxy-protecting group, and Rb is a carboxy-protecting group, which methods are carried out by conversion of the intermediate of formula XIX wherein Ra and Rc are each independently of the other hydrogen or a hydroxy-protecting group, and Rb is a carboxy-protective group.
申请公布号 US2005033086(A1) 申请公布日期 2005.02.10
申请号 US20040481704 申请日期 2004.09.10
申请人 OHRLEIN REINHOLD;BAISCH GABRIELE;KIRNER HANS JURG;BIENEWALD FRANK;BURKHARDT STEPHAN;STUDER MARTIN 发明人 OHRLEIN REINHOLD;BAISCH GABRIELE;KIRNER HANS JURG;BIENEWALD FRANK;BURKHARDT STEPHAN;STUDER MARTIN
分类号 C07C67/307;C07B53/00;C07B61/00;C07C67/30;C07C67/31;C07C69/67;C07C69/675;C07C69/708;C07C69/716;C07C69/732;C07C69/738;C07C227/06;C07C227/16;C07C227/32;C07C229/22;C07C231/02;C07C235/06;C07C235/74;C07C247/12;C07C253/30;C07D207/34;C12P7/62;(IPC1-7):C07C229/22 主分类号 C07C67/307
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