发明名称 |
IMPROVED AMINODEXTRAN COMPOSITIONS AND CONJUGATES AND METHODS OF MAKING AND USING THEM |
摘要 |
A composition containing polydisperse aminodextran polymer molecules is soluble in an aqueous solution at a concentration of 10 mg/ml. The molecules therein have a narrow size distribution characterized by an average molecule mean hydrodynamic diameter of greater than 115 nm, a polydispersity index of between 0.10 and 0.47, an average molecular weight (MW) greater than 3 million daltons, and an amine content of greater than 50 amines per molecule. Similar soluble compositions contain the polymer molecules with an average MW of greater than 7 million daltons. These compositions are useful in forming reagents by conjugation with proteins for labeling cells. Methods of making these compositions and reagents from conventional mixtures of aminodextran polymers involve fractionation on column chromatography. |
申请公布号 |
WO2005012870(A2) |
申请公布日期 |
2005.02.10 |
申请号 |
WO2004US23357 |
申请日期 |
2004.07.22 |
申请人 |
BECKMAN COULTER, INC. |
发明人 |
LEDIS, STEPHEN, L.;SIIMAN, OLAVI;HEALY, CYNTHIA |
分类号 |
A61K31/715;A61K47/48;C08B37/00;C08B37/02;G01N33/548 |
主分类号 |
A61K31/715 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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