发明名称 |
Hypoglycaemic peptides and methods of use thereof |
摘要 |
A peptide of the formula (Xaa)n1-Xaa1-His-Thr-Asp(Xaa)n2, wherein Xaa is any amino acid; Xaa1 is a hydrophobic amino acid, preferably Gly or Val; n1 is 0-10; and n2 is 0-10; and use thereof in regulating in vivo blood glucose levels in a human or other mammal, particularly in the treatment of Type 2 diabetes in a human. Preferably, the peptide is a tetrapeptide selected from Gly-His-Thr-Asp and Val-His-Thr-Asp. These hypoglycaemic peptides are isolated from human urine and they also have been chemically synthesized.
|
申请公布号 |
US2005032706(A1) |
申请公布日期 |
2005.02.10 |
申请号 |
US20040481662 |
申请日期 |
2004.08.24 |
申请人 |
INTERNATIONAL DIABETES INSTITUTE |
发明人 |
ZIMMET PAUL ZEV;NG FRANK MAN-WOON |
分类号 |
A61K38/00;A61K38/07;A61K38/08;A61P5/50;C07K5/02;C07K5/103;C07K5/113;C07K7/04;(IPC1-7):A61K38/10;C07K7/06;C07K7/08 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|