SULFONAMIDE DERIVATIVE HAVING ISOXAZOLE RING

摘要

A compound represented by the general formula (I-A): (Chemical formula 1) (I-A) (wherein R<1> is hydroxy, etc.; R<2> is optionally substituted lower alkyl, etc.; R<3> is hydrogen, etc.; R<4> is optionally substituted allylene, etc.; R<5> is a group represented by the formula (Chemical formula 2) (1) or (2) and R<6> is optionally substituted aryl, etc.), an optically active isomer thereof, a pharmaceutically acceptable salt of either, or a solvate of any of these; and a metalloprotease inhibitor containing any of these.