发明名称 |
Antibody CDR polypeptide sequences with restricted diversity |
摘要 |
<p>The invention provides variant CDRs comprising highly restricted amino acid sequence diversity. These polypeptides provide a flexible and simple source of sequence diversity that can be used as a source for identifying novel antigen binding polypeptides. The invention also provides these polypeptides as fusion polypeptides to heterologous polypeptides such as at least a portion of phage or viral coat proteins, tags and linkers. Libraries comprising a plurality of these polypeptides are also provided. In addition, methods of and compositions for generating and using these polypeptides and libraries are provided.</p> |
申请公布号 |
AU2004261980(A1) |
申请公布日期 |
2005.02.10 |
申请号 |
AU20040261980 |
申请日期 |
2004.07.28 |
申请人 |
GENENTECH, INC. |
发明人 |
FREDERIC A. FELLOUSE;SACHDEV S. SIDHU |
分类号 |
C07K16/00;C07H21/04;C07K14/705;C07K16/22;C07K16/32;C12N15/13;C12N15/62;C12P21/04 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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