A coating for controlled release of a therapeutic agent

摘要

A composition for coating the surface of an implantable medical device is discussed. The composition comprises: a basecoat matrix, including at least one agent, in therapeutic dosages, incorporated in a first polymeric material, the basecoat matrix being affixed to the surface of the implantable medical device; and a topcoat, including a second polymeric material, affixed to the basecoat matrix for controlling the elution rate of the at least one agent. The at least one agent can also be incorporated in a fluropolymer together with a topcoat including an acrylic polymer. An implantable medical device including the coating is also discussed.