发明名称 |
METHODS OF SCREENING FOR AGONISTIC ANTIBODIES |
摘要 |
<p>Cell strains with ligand-dependent (factor-dependent) proliferation are super-infected with antibody libraries against each of the various receptor chains. Antibody genes are recovered from strains that autonomously grow by the autocrine stimulation by agonistic antibodies formed by appropriate combinations, enabling effective screening of agonistic antibodies. In this method, effective screening can be carried out using antibodies as libraries. Furthermore, the manipulations are simple, and there is no need for complicated operations.</p> |
申请公布号 |
EP1505148(A1) |
申请公布日期 |
2005.02.09 |
申请号 |
EP20030719213 |
申请日期 |
2003.04.25 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
KOJIMA, TETSUO;SENOO, CHIAKI |
分类号 |
A61P25/00;A61P37/00;C12P21/08;C40B30/04;G01N33/50;G01N33/68;(IPC1-7):C12N15/00;G01N33/15;A61K39/395;C12Q1/02;C12N5/10;C07K16/44 |
主分类号 |
A61P25/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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