发明名称 |
BLOCK COPOLYMER REDUCED IN IMPURITY CONTENT, POLYMERIC CARRIER, PHARMACEUTICAL PREPARATIONS IN POLYMERIC FORM AND PROCESS FOR THE PREPARATION OF THE SAME |
摘要 |
Block copolymer or salt thereof comprises polyethylene glycol and polyacidic amino acid and 10 wt% impurity. Independent claims are also included for: (1) preparation of a copolymer or salt thereof, by refining polyethylene glycol derivative with ion exchange resin, removing protective group if necessary, and treating with absorbing resin; (2) a polymer carrier wherein the polyacidic amino acid is condensed with anthra cycling type caner controlling residual groups; (3) preparation of the carrier; and (4) a polymer medicine comprising a block copolymer-medicine composite wherein anthra cycling cancer controlling agent is wrapped in the core of a polymer micelle. |
申请公布号 |
PL366773(A1) |
申请公布日期 |
2005.02.07 |
申请号 |
PL20020366773 |
申请日期 |
2002.06.19 |
申请人 |
NIPPON KAYAKU KK;JAPAN SCIENCE AND TECHNOLOGY AGENCY;SAKURAI YASUHISA |
发明人 |
NAKANISHI TAKESHI;SHIMIZU KAZUHISA;UEHARA RYUJI;SUZUKI MASANOBU;MACHIDA MEGUMI;AKUTSU TOMOKO;FUKUSHIMA SHIGETO |
分类号 |
C08G69/40;A61K31/704;A61K47/48;A61P35/00 |
主分类号 |
C08G69/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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