TANSHINONE IIA FROM SALIVA MILTIORRHIZA BUNGE FOR INHIBITING DIFFERENTIATION AND BONE RESORPTION OF OSTEOCLAST

摘要

PURPOSE: Tanshinone IIA which is originated from Saliva miltiorrhiza Bunge and has an effect of inhibiting differentiation and bone resorption of an osteoclast is provided. Therefore, the tanshinone IIA is expected to become a material for development of drugs for treating osteosis, rheumatoid arthritis and periodontal disease. CONSTITUTION: The tanshinone II-A is originated from Saliva miltiorrhiza Bunge and represented by the formula 1 which inhibits the differentiation and bone resorption of an osteoclast. An inhibitor of osteoclast differentiation contains the tanshinone II-A as an effective component. The tanshinone II-A inhibits the expression of calcitonin receptors, c-Src and integrin. An inhibitor of bone resorption contains the tanshinone II-A as an effective component. The tanshinone II-A blocks the activity of Akt, ERK and NF-κB induced by RANKL by inhibition of the expression of RANKL from the osteoclast precursor.