5-Membered heterocyclic compounds as inhibitors of leukocyte adhesion and VLA-4 antagonists and pharmaceutical composition containing thereof

摘要

Described are compounds of the general formula (I), in which the symbols B, D, E, R, W, Y, Z, b, c, d, e, f, g and h have specific meanings in the claims. These compounds are inhibitors of adhesion and migration of leukocytes and/or antagonists of VLA-4 adhesion receptor, which pertains to the group of integrins. Described is also pharmaceutical composition containing thereof and the use of the compounds of the general formula (I) for preparing medicaments intended for treating or prophylaxis of diseases caused by undesired extent of leukocyte adhesion and/or migration or in which the cell-cell or cell-matrix interaction play a role, which are based on interaction of VLA-4 receptors with ligands thereof, such as inflammatory processes, rheumatoid arthritis or allergic diseases.