发明名称 |
METHODS OF SYNTHESIS OF ACYLOXYALKYL COMPOUNDS |
摘要 |
Disclosed herein are methods for synthesizing 1-(acyloxy)-alkyl prodrug derivatives of drugs through oxidation of 1-acyl-alkyl derivatives of drugs under anhydrous reaction conditions. The methods typically proceed stereospecifically, in high yield, do not require the use of activated intermediates and/or toxic compounds and are readily amenable to scale-up. |
申请公布号 |
WO2005010011(A2) |
申请公布日期 |
2005.02.03 |
申请号 |
WO2004US23066 |
申请日期 |
2004.07.15 |
申请人 |
XENOPORT, INC.;GALLOP, MARK, A.;BHAT, LAXMINARAYAN |
发明人 |
GALLOP, MARK, A.;BHAT, LAXMINARAYAN |
分类号 |
C07C67/42;C07C68/06;C07C69/66;C07C69/96;C07C229/00;C07C269/06;C07C271/22;C07C303/30;C07C309/75;C07D213/46;C07F;C07F9/02 |
主分类号 |
C07C67/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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