发明名称 |
Method of pulmonary administration of an agent |
摘要 |
A method for administering a therapeutic or diagnostic agent to a subject is described. The method includes providing a suspension of liposomes comprised of one or more of vesicle-forming lipids selected from (i) a vesicle-forming lipid derivatized with a hydrophilic polymer and (ii) a neutral lipopolymer, said liposomes being associated with said therapeutic or diagnostic agent, forming an aerosol of said liposome suspension; and administering the aerosol to the subject by inhalation. The liposome formulation delivers intact liposomal particles to the respiratory tract of said subject to form a depot of therapeutic agent therein with no observable provocation of an immune response, as measured by neutrophil or macrophage cell count in the lung after administration.
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申请公布号 |
US2005025822(A1) |
申请公布日期 |
2005.02.03 |
申请号 |
US20040856559 |
申请日期 |
2004.05.27 |
申请人 |
WONG FRANCES M.P.;DAS ANUK;SEIDEMAN JONATHAN;GUO LUKE;HUANG ANTHONY |
发明人 |
WONG FRANCES M.P.;DAS ANUK;SEIDEMAN JONATHAN;GUO LUKE;HUANG ANTHONY |
分类号 |
A61K9/00;A61K9/127;(IPC1-7):A61K9/127;C12N15/88 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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地址 |
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