Carboxylic acid derivatives, processes for the preparation thereof and pharmaceutical aggents comprising the same as active ingredient

摘要

A carboxylic acid derivative of formula (I) wherein R<1 >is COOH, COOR<6 >etc.; A is alkylene etc.; R<2 >is alkyl, alkenyl, alkynyl etc.; B is carbocyclic ring or heterocyclic ring; R<4 >is alkyl, cycloalkyl etc.; R<6 >is carbocyclic ring or heterocyclic ring; or non-toxic salts thereof, a process for the preparation thereof and a pharmaceutical agent comprising the same as active ingredient. The compound of the formula (I) can bind to Prostaglandin E2 receptors, especially, EP3 receptor and/or EP4 receptor and show the antagonizing activity, and useful for the prevention and/or treatment of disease, for example, pain, allergy, Alzheimer's disease, cancer.