5-MEMBERED HETEROCYCLE-BASED P38 KINASE INHIBITORS

摘要

Provided are 5-membered heterocycle-based p38 kinase inhibitors. Further provided are pyrazole and imidazole-based p38 kinase, including p38.alpha. a nd p38.beta. kinase, inhibitors. Pharmaceutical compositions containing the compounds are also provided. Methods of use of the compounds and composition s are also provided, including method of treatment, prevention, or amelioratio n of one or more symptoms of p38 kinase mediated diseases and disorders, including, but not limited to, inflammatory diseases and disorders.