发明名称 |
METHOD FOR IDENTIFYING TFF2 REGULATING AGENTS AND AGENTS IDENTIFIED USING SAID METHOD |
摘要 |
Agents useful for modulating the dioxin/aryl hydrocarbon receptor (AhR) can now be identified by determining the binding to said receptor and whether said agent suppresses or inhibits the expression of a gene substantially consisting of a sequence according to one of SEQ.ID. NO. 1 and. SEQ.ID. NO. 2; a nucleotide sequence functionally homologous, or substantially homologous, or at least 90 % identical to one of SEQ.ID. NO. 1 and SEQ.ID. NO. 2; and a nucleotide sequence complementary to the nucleotide sequence of SEQ.ID. NO. 1 or SEQ.ID. NO. 2. Such agents find utility in pharmaceutical compositions and methods for the prevention, alleviation or treatment of diseases involving gastrointestinal hyperplasia, such as gastrointestinal cancer or gastric cancer.
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申请公布号 |
WO2004102195(A8) |
申请公布日期 |
2005.02.03 |
申请号 |
WO2004SE00748 |
申请日期 |
2004.05.13 |
申请人 |
INDEX PHARMACEUTICALS AB;ANDERSSON, PATRIK;KOUZNETSOV, NIKOLAI;POELLINGER, LORENZ;VON STEIN, PETRA |
发明人 |
ANDERSSON, PATRIK;KOUZNETSOV, NIKOLAI;POELLINGER, LORENZ;VON STEIN, PETRA |
分类号 |
A01K67/027;A61K38/00;A61K38/55;A61K48/00;C07K14/705;C12N15/85;C12Q;G01N33/566;G01N33/574;(IPC1-7):G01N33/53 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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