Methods for the identification of inhibitors of fumarate reductase as antibiotics

摘要

The present inventors have discovered that fumarate reductase is essential for normal fungal pathogenicity. Specifically, the inhibition of fumarate reductase gene expression in fungi results in drastically reduced pathogenicity. Thus, fumarate reductase is useful as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit fumarate reductase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.